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Products Details
Product Description
– Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2].
Web ID
– HY-122080
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C38H56N4O4
References
– [1]Capurro V, et al. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer’s disease. PLoS One. 2013;8(2):e56870.|[2]Cavalli A, et al. A small molecule targeting the multifactorial nature of Alzheimer’s disease. Angew Chem Int Ed Engl. 2007;46(20):3689-92.
CAS Number
– 616885-87-1
Molecular Weight
– 632.88
SMILES
– O=C1C(NCCCCCCN(CC2=CC=CC=C2OC)CC)=CC(C(NCCCCCCN(CC3=CC=CC=C3OC)CC)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;Beta-secretase;Cholinesterase (ChE)
Isoform
– AChE;BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
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