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Meldonium (dihydrate)
$32 – $80
Products Details
Product Description
– Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor[1][2].
Web ID
– HY-B1836A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C6H18N2O4
Citations
– J Pharmaceut Biomed. 2020, 113870.|J Anim Sci. 2022 Mar 5;skac069.
References
– [1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780.|[2]Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.
CAS Number
– 86426-17-7
Molecular Weight
– 182.22
Compound Purity
– 99.0
SMILES
– C[N+](C)(C)NCCC([O-])=O.O.O
Clinical Information
– Launched
Research Area
– Metabolic Disease; Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 4.85 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)
Target
– Mitochondrial Metabolism
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
