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Products Details
Product Description
– MEK1/2-IN-2 is a potent ATP-competitive MEK1/2 inhibitor and shows equipotent inhibition of WT MEK1/2 and a panel of MEK1/2 mutant cell lines[1].
Web ID
– HY-145701
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H22ClFN6O
References
– [1]Ramulu Poddutoori, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022 Mar 10;65(5):4350-4366.
Molecular Weight
– 512.97
SMILES
– ClC1=CC(OC2=CC=CC=N2)=CC=C1C3=C(F)C=C(N=CC4=C5N(C6CCN(CC#N)CC6)C=N4)C5=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MEK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
