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MEG (hemisulfate)
SKU
HY-138454-Get quote
Category Reference compound
Tags Immunology/Inflammation, Inflammation/Immunology, NO Synthase
Products Details
Product Description
– MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC50s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock[1][2][3][4].
Web ID
– HY-138454
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C3H9N3S.1/2H2O4S
References
– [1]Southan GJ, et, al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol. 1996 Feb;117(4):619-32.|[2]Szabó C, et, al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem. 1997 Apr 4;272(14):9030-6.|[3]Guven A, et, al. Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite. J Pediatr Surg. 2011 Sep;46(9):1746-52.|[4]Guven A, et, al. Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury. Ren Fail. 2008;30(7):747-54.
CAS Number
– 3979-00-8
Molecular Weight
– 168.23
SMILES
– NC(NCCS)=N.O=S(O)(O)=O.[1/2]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NO Synthase
Isoform
– iNOS
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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