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Product Description
– Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].
Web ID
– HY-17437
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C17H16F6N2O
References
– [1]Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.|[2]Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545.|[3]Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403.|[4]Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.
CAS Number
– 53230-10-7
Molecular Weight
– 378.31
SMILES
– O[C@H]([C@]1([H])NCCCC1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32
Clinical Information
– Launched
Research Area
– Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Autophagy;Parasite;Potassium Channel;ROS Kinase;SARS-CoV
Isoform
– Plasmodium
Pathway
– Anti-infection;Autophagy;Membrane Transporter/Ion Channel;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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