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Products Details
Product Description
– MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication[1].
Web ID
– HY-156442
Shipping
– Room temperature
Molecular Formula
– C20H11F4N3O2
References
– [1]Anna Luganini, et al. Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication. Antiviral Res. 2023 Oct 16:219:105734.
CAS Number
– 2241027-61-0
Molecular Weight
– 401.31
SMILES
– O=C(C1=C2C=CC=CN2N=C1O)NC3=C(F)C(F)=C(C4=CC=CC=C4)C(F)=C3F
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Lactate Dehydrogenase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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