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Products Details
Product Description
– MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity[1].
Web ID
– HY-151170
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H17Cl3FN3O3
References
– [1]Margarida Espadinha, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637.
Molecular Weight
– 532.78
SMILES
– O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3=CC=C(Cl)C=C3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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