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Products Details
Product Description
– MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].
Web ID
– HY-151169
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H22Cl2N6O3
References
– [1]Espadinha M, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637.
Molecular Weight
– 609.47
SMILES
– O=C1NC2=CC(Cl)=CC=C2[C@@]13N(C4=CC=C(Cl)C=C4)N=C([C@@H]3C5=CC(O)=CC=C5)C(NC6=CC(N7N=CC=C7)=CC=C6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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