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MDL 101146

SKU HY-117668-Get quote Category Reference compound Tags Elastase, Infection; Inflammation/Immunology, Metabolic Enzyme/Protease

Products Details

Product Description

– MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].

Web ID

– HY-117668

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C29H37F5N4O6

References

– [1]Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl|[2]M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8.

CAS Number

– 149859-17-6

Molecular Weight

– 632.62

SMILES

– O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O

Clinical Information

– No Development Reported

Research Area

– Infection; Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Elastase

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.