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Products Details
Product Description
– MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein[1].
Web ID
– HY-150259
Shipping
– Room temperature
Molecular Formula
– C35H38N4O7S
References
– [1]Lier S, et al. A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem. 2022 Feb;119:105505.
Molecular Weight
– 658.76
SMILES
– O=C(S/C(C1=O)=CC2=CC=C(C=C2)C(C)C)N1CCCCCCCCNC(C3=CC=C4C(N(C(C4=C3)=O)C5CCC(NC5=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Myc;PROTACs
Pathway
– Apoptosis;PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
