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Products Details
Product Description
– Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity[1].
Web ID
– HY-100763
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C45H46N4O6S2
References
– [1]Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.
CAS Number
– 2042211-12-9
Molecular Weight
– 803.00
SMILES
– O=C(NS(=O)(C1=CC=C(NCCSC2=CC=CC=C2)C([N+]([O-])=O)=C1)=O)C3=CC=C(NC(C(C=C4)=CC=C4C(C5=C(C)C=C(C(C)(C)CCC6(C)C)C6=C5)=C)=O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Pathway
– Apoptosis
Product type
– Reference compound
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