MC-GGFG-AM-(10Me-11F-Camptothecin)

$980$3,900

$980
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Products Details

Product Description

– MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].

Web ID

– HY-153360

Storage Temperature

– -20°C (Powder, sealed storage, away from moisture and light)

Shipping

– Blue Ice

Applications

– Cancer-programmed cell death

Molecular Formula

– C51H56FN9O14

References

– [1]Madera L, et al. ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload[J]. Cancer Research, 2023, 83(7_Supplement): 2658-2658.

CAS Number

– 2873460-70-7

Molecular Weight

– 1038.04

Compound Purity

– 98.06

SMILES

– FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Drug-Linker Conjugates for ADC;Topoisomerase

Isoform

– Topo I

Pathway

– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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