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MAZ51
$96 – $880
Products Details
Product Description
– MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2].
Web ID
– HY-116624
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H18N2O
References
– [1]Kirkin V, et al. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur J Biochem. 2001 Nov;268(21):5530-40.|[2]Kirkin V, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer. 2004 Dec 20;112(6):986-93.
CAS Number
– 163655-37-6
Molecular Weight
– 314.38
Compound Purity
– 98.61
SMILES
– CN(C1=C2C=CC=CC2=C(C=C1)/C=C3C(NC4=C/3C=CC=C4)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 11.36 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;VEGFR
Isoform
– VEGFR3/Flt-4
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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