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Products Details
Product Description
– Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.
Web ID
– HY-50101
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C21H27N5
Citations
– Br J Haematol. 2022 Dec 19.|Patent. US20220273751A1.|PLoS One. 2016 Mar 21;11(3):e0151765.|Oncol Rep. 2022 Apr;47(4):68.
References
– [1]Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.|[2]Chow LN, et al. Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. PLoS One. 2016 Mar 21;11(3):e0151765.|[3]Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.
CAS Number
– 558447-26-0
Molecular Weight
– 349.47
Compound Purity
– 95.0
SMILES
– NCCCCN(CC1=NC2=C(N1)C=CC=C2)[C@@H]3C4=C(CCC3)C=CC=N4
Clinical Information
– Phase 3
Research Area
– Infection; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– CXCR;HIV
Isoform
– CXCR4;HIV-1
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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