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MARK-IN-4
$310 – $1,250
Products Details
Product Description
– MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer’s disease[1].
Web ID
– HY-112266
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C21H23N7OS
References
– [1]Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016;26(17):4362-4366.
CAS Number
– 1990492-86-8
Molecular Weight
– 421.52
Compound Purity
– 98.99
SMILES
– O=C(C1=CC(C2=C3N=CC(C4=CN(C)N=C4)=CN3N=C2)=CS1)N[C@H]5[C@H](N)CCCC5
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– AMPK
Pathway
– Epigenetics;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
