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Products Details
Product Description
– Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].
Web ID
– HY-13004S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H35D6F2N5O
References
– [1]Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472|[2]Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802.|[3]Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64.|[4]Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1033699-22-7
Molecular Weight
– 519.70
SMILES
– C(C[C@H](NC(=O)C1CCC(F)(F)CC1)C2=CC=CC=C2)N3[C@@H]4C[C@@H](C[C@H]3CC4)N5C(C(C([2H])([2H])[2H])C([2H])([2H])[2H])=NN=C5C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cancer; Endocrinology
Solubility
– 10 mM in DMSO
Target
– CCR;HIV;Isotope-Labeled Compounds
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
