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Products Details
Product Description
– MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures[1].
Web ID
– HY-149234
Shipping
– Room temperature
Molecular Formula
– C25H22N4O5
References
– [1]Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352.|[2]Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352.
Molecular Weight
– 458.47
SMILES
– COC1=CC(COC2=CC=C(C=C2)C3=NOC(C4=CC=C5NN=CC5=C4)=N3)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Monoamine Oxidase
Isoform
– MAO-A;MAO-B
Pathway
– Neuronal Signaling
Product type
– Reference compound
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