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Manzamine A hydrochloride
1,062 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
Web ID
– T38441
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C36H45ClN4O
References
– Hamann M, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease. J Nat Prod. 2007;70(9):1397-1405.
CAS Number
– 104264-80-4
Molecular Weight
– C36H45ClN4O
SMILES
– Cl.[H][C@]12C[C@]34CN5CC[C@@]3([H])C(=C[C@@](O)(CCC=C/CCCC5)[C@]4([H])N1CCCCC=C/2)c1nccc2c3ccccc3[nH]c12
Pathway
– Others
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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