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Products Details
Product Description
– Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].
Web ID
– HY-N10443
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H26O5
References
– [1]RodrÃguez-Hernández KD, et al. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorg Chem. 2020 Jul;100:103894.
CAS Number
– 5224-54-4
Molecular Weight
– 406.47
SMILES
– O=C1C=C(C2=CC=CC=C2)C3=C(O)C(C/C=C(C)C)=C(O)C(C(CC(C)C)=O)=C3O1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Parasite;Reactive Oxygen Species
Isoform
– Trypanosoma
Pathway
– Anti-infection;Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
