Download Files:
Mal-PEG2-VCP-Eribulin
$1,000 – $2,880
Products Details
Product Description
– Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates[1].
Web ID
– HY-128870
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C70H99N7O21
References
– [1]Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.|[2]Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.
CAS Number
– 2130869-18-8
Molecular Weight
– 1374.57
Compound Purity
– 99.82
SMILES
– C=C1C[C@@]2([H])O[C@@]1([H])CC[C@]3([H])O[C@](C([C@H](C)C3)=C)([H])C[C@@]4([H])[C@]([C@@H](OC)[C@@H](C[C@H](O)CNC(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)O4)([H])CC(C[C@]7([H])O[C@]8([H])[C@]9([H])O[C@@]%10(O[C@@]%11([H])[C@@](O[C@]9([H])[C@@]%11([H])O[C@@]8([H])CC7)([H])C%10)CC2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 10 mg/mL (7.28 mM)
Target
– Drug-Linker Conjugates for ADC
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
