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Macozinone
$144 – $1,140
Products Details
Product Description
– Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].
Web ID
– HY-12903
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H23F3N4O3S
References
– [1][3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones.
EMBO Mol Med. 2014 Mar;6(3):372-83.
CAS Number
– 1377239-83-2
Molecular Weight
– 456.48
Compound Purity
– 99.68
SMILES
– O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1
Clinical Information
– Phase 2
Research Area
– Infection
Solubility
– DMSO : 6.4 mg/mL (ultrasonic)
Target
– Antibiotic;Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
