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Products Details
Product Description
– M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model[1].
Web ID
– HY-155819
Shipping
– Room temperature
Molecular Formula
– C38H41Cl2N3O8S
References
– [1]Rizzi A, et al. Optimization of M3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J Med Chem. 2023 Aug 24;66(16):11476-11497..
Molecular Weight
– 770.72
SMILES
– COC1=C(OCC)C=C([C@@H](OC(C2=CC=C(CN[C@](C(O[C@H]3CN4CCC3CC4)=O)(CO)C5=CC=CC=C5)S2)=O)CC6=C(Cl)C=[N+]([O-])C=C6Cl)C=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– mAChR;Phosphodiesterase (PDE)
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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