Download Files:
Products Details
Product Description
– M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model[1].
Web ID
– HY-155819
Shipping
– Room temperature
Molecular Formula
– C38H41Cl2N3O8S
References
– [1]Rizzi A, et al. Optimization of M3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J Med Chem. 2023 Aug 24;66(16):11476-11497..
Molecular Weight
– 770.72
SMILES
– COC1=C(OCC)C=C([C@@H](OC(C2=CC=C(CN[C@](C(O[C@H]3CN4CCC3CC4)=O)(CO)C5=CC=CC=C5)S2)=O)CC6=C(Cl)C=[N+]([O-])C=C6Cl)C=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– mAChR;Phosphodiesterase (PDE)
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
