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Products Details
Product Description
– M24 is a Mcl-1 selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with Ki value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells[1].
Web ID
– HY-115928
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C44H40Cl3N5O11S
References
– [1]Xiao Liang, et al. Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors. Bioorg Chem. 2022 Apr;121:105643.
CAS Number
– 2761947-05-9
Molecular Weight
– 953.24
SMILES
– CC1=CC(OCCOC2=CC=C(C=C2)CN3CC(N(C3=O)CC(NC(C(NS(=O)(C4=CC([N+]([O-])=O)=C(C=C4)Cl)=O)=O)CC5=CC=C(C=C5)OCC6=CC=C(C=C6)Cl)=O)=O)=CC(C)=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Pathway
– Apoptosis
Product type
– Reference compound
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