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Lys-CoA (TFA)
$350 – $5,250
Products Details
Product Description
– Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].
Web ID
– HY-131035
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H54F3N10O21P3S
References
– [1]Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003;11(15):3307-3313.|[2]Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 2000;5(3):589-595.
Molecular Weight
– 1108.82
Compound Purity
– 99.42
SMILES
– OC(C(F)(F)F)=O.O[C@H](C(C)(COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)(O)=O)(O)=O)C)C(NCCC(NCCSCC(NCCCC[C@H](NC(C)=O)C(N)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O : 70 mg/mL (ultrasonic)
Target
– Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
