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Products Details
Product Description
– LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].
Web ID
– HY-118178
Shipping
– Room temperature
Molecular Formula
– C17H12Cl2N2O
References
– [1]Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.|[2]Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186.
CAS Number
– 26766-35-8
Molecular Weight
– 331.20
SMILES
– OC(C1=CC=C(C=C1)Cl)(C2=CN=CN=C2)C3=CC=C(C=C3)Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Monoamine Oxidase
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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