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LY379268
$350 – $2,850
Products Details
Product Description
– LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].
Web ID
– HY-103558
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C7H9NO5
References
– [1]J A Monn, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40.|[2]E F Sharpe, et al. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol. 2002 Mar;135(5):1255-62.|[3]Juan Turati, et al. Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro. Neurochem Int. 2020 Nov;140:104837.
CAS Number
– 191471-52-0
Molecular Weight
– 187.15
Compound Purity
– 99.84
SMILES
– O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 0.1 M NaOH : 200 mg/mL (ultrasonic;adjust pH to 8 with NaOH)|H2O : 2 mg/mL (ultrasonic;adjust pH to 10 with NaOH)
Target
– mGluR
Isoform
– mGluR2;mGluR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
