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LY2812223
$670 – $6,150
Products Details
Product Description
– LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively)[1].
Web ID
– HY-18760
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C10H12N4O4S
References
– [1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58(18):7526-48.
CAS Number
– 1311385-20-2
Molecular Weight
– 284.29
Compound Purity
– 98.0
SMILES
– [H][C@]1(C(O)=O)[C@]([C@]1([H])[C@](N)(C(O)=O)C2)([H])[C@@H]2SC3=NN=CN3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 28.75 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– mGluR
Isoform
– mGluR2;mGluR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
