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Products Details
Product Description
– LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
Web ID
– HY-15643
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H18N2O2
Citations
– Int J Mol Sci. 2023 Jul 28, 24(15), 12079.|Cancer Cell Int. 2021 Jun 5;21(1):291.
References
– [1]Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11.|[2]Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69(5):1941-50.|[3]El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2.|[4]Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol Exp Ther. 2005 Sep;314(3):1134-43.
CAS Number
– 154447-38-8
Molecular Weight
– 306.36
SMILES
– O=C1C=C(N2CCNCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Potassium Channel;TNF Receptor
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
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