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LY 254155

SKU HY-14523-Get quote Category Tags , ,

Products Details

Product Description

– LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

Web ID

– HY-14523

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C19H23N5O6S

References

– [1]Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6.

CAS Number

– 135503-67-2

Molecular Weight

– 449.48

SMILES

– O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Antifolate

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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