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Products Details
Product Description
– LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) with an IC50 value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular ROS, thus induces apoptosis. LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model[1].
Web ID
– HY-152207
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H38N8O3S
References
– [1]Chang X, et al. Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group. Eur J Med Chem. 2023 Jan 15;246:115014.
Molecular Weight
– 566.72
SMILES
– CCCCOC1=CC=CC(CC(NC2=NN=C(C=C2)N3CCC(CC3)NC4=NN=C(S4)NC(CCCC)=O)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Glutaminase
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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