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LT175
SKU
HY-121900-1mg
Category Reference compound
Tags Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor, Endocrinology; Metabolic Disease, PPAR
$74
Only 1000 item(s) left in stock.
Products Details
Product Description
– LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
Web ID
– HY-121900
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C21H18O3
References
– [1]Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920.
CAS Number
– 862901-87-9
Molecular Weight
– 318.37
SMILES
– O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– PPAR
Isoform
– PPARα;PPARγ
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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