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Products Details
Product Description
– LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated LSD1 (Lysine specific demethylase-1) inhibitor, with an IC50 of 0.956 µM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α. LSD1-IN-21 shows good anticancer and anti-inflammatory activity[1].
Web ID
– HY-147697
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H25N5O2S
References
– [1]Tasneem S, et al. Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Bioorg Chem. 2022 May 21;126:105885.
Molecular Weight
– 447.55
SMILES
– COC1=CC=C(C=C1)/C=N/NC2=C(C(C3=CC=C(C=C3)OC)=NC(SCC(C)C)=N2)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase;TNF Receptor
Isoform
– KDM1/LSD1
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
