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Products Details
Product Description
– LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation[1].
Web ID
– HY-151192
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H8BrF2N
References
– [1]Hideaki Niwa, et al. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Med. Chem. Lett. 2022.
CAS Number
– 2821068-07-7
Molecular Weight
– 248.07
SMILES
– N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
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