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Products Details
Product Description
– LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].
Web ID
– HY-153058
Shipping
– Room temperature
Molecular Formula
– C16H12F2N6
References
– [1]Jean TASSEL, et al. Kinase modulators and methods of use thereof. Patent. WO2022104206.
CAS Number
– 2770269-44-6
Molecular Weight
– 326.30
SMILES
– FC1=CC=CC(F)=C1C2=NC3=C(C4=C(N2CCC5)N5N=C4)NN=C3
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– AMPK;JAK;LRRK2
Isoform
– NUAK1;Tyk2
Pathway
– Autophagy;Epigenetics;JAK/STAT Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
