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Products Details
Product Description
– LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively[1].
Web ID
– HY-131907
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H24N4O5
References
– [1]Yamada Y, et al. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity [published online ahead of print, 2020 Nov 19]. J Med Chem. 2020;10.1021/acs.jmedchem.0c01215.
CAS Number
– 2253951-38-9
Molecular Weight
– 412.44
SMILES
– C[C@@H](C1=NC=CN1CC2=NOC(C#CC3=CC=C(C=C3)OCC(CO)(CO)N)=C2)O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
