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Products Details
Product Description
– LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg)[1].
Web ID
– HY-156085
Shipping
– Room temperature
Molecular Formula
– C27H27N3O5S
References
– [1]Liu J, et al. Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J Med Chem. 2023 Sep 6.. .
Molecular Weight
– 505.59
SMILES
– O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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