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LP-922056
$88 – $715
Products Details
Product Description
– LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats[1][2].
Web ID
– HY-131034
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H9ClN2O2S2
References
– [1]James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528.|[2]Robert Brommage, et al. NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 Jan 8;7:2.
CAS Number
– 1365060-22-5
Molecular Weight
– 300.78
Compound Purity
– 98.08
SMILES
– O=C(O)CSC1=C2C(C(C3CC3)=C(Cl)S2)=NC=N1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Wnt
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
