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Products Details
Product Description
– Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].
Web ID
– HY-17390B
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H19Cl2N3O
References
– [1]Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35.|[2]Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. |[3]Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85.|[4]Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27(6):479-89.
CAS Number
– 54810-23-0
Molecular Weight
– 364.27
SMILES
– CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1.[H]Cl
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Dopamine Receptor
Isoform
– 5-HT2 Receptor;D1 Receptor;D2 Receptor;D4 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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