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Products Details
Product Description
– Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Web ID
– HY-136703
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C37H46N4O6
References
– [1]Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.|[2]Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.
CAS Number
– 192725-39-6
Molecular Weight
– 642.78
SMILES
– O=C(N[C@@H](CC1=CC=CC=C1)C[C@H](O)[C@@H](NC(COC2=C(C)C=CC=C2C)=O)CC3=CC=CC=C3)[C@H](C(C)C)N(C(N4)=O)CCC4=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HIV Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
