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Product Description
– Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-117652
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C14H18O3
References
– [1]Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127.|[2]Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140.
CAS Number
– 136171-87-4
Molecular Weight
– 234.29
SMILES
– C/C=C/C#CC#CC(O)C(O)/C=C/CCCO
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;MDM-2/p53
Isoform
– Bax;Bcl-2
Pathway
– Apoptosis
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
