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LML134
$166 – $2,250
Products Details
Product Description
– LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1].
Web ID
– HY-128656
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H29N5O3
References
– [1]Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247.
CAS Number
– 1542135-76-1
Molecular Weight
– 375.47
Compound Purity
– 99.43
SMILES
– O=C(OC1CCN(C2=NN(C)C(C=C2)=O)CC1)N3CCN(C4CCC4)CC3
Clinical Information
– Phase 2
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 12.5 mg/mL (ultrasonic)
Target
– Histamine Receptor
Isoform
– H3 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
