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Product Description
– Liothyronine-13C9,15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
Web ID
– HY-A0070AS1
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C6 13C9H12I3 15NO4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Lin KH, et al. Stimulation of proliferation by 3,3′,5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.|[3]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3′,5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31195(1):385-92.|[4]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 120(11):3622-34.
CAS Number
– 1213569-04-0
Molecular Weight
– 660.90
SMILES
– I[13C]([13CH]=[13C]([13CH]=[13C]1I)[13CH2][13C@H]([15NH2])[13C](O)=O)=[13C]1OC2=CC(I)=C(C=C2)O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Thyroid Hormone Receptor
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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