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Liensinine
$60 – $320
Products Details
Product Description
– Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1].
Web ID
– HY-N0484
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C37H42N2O6
References
– [1]Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79.|[2]Liang Pang, et al. Protective effect of liensinine on periodontitis through its antioxidant effect in mice. Journal of the Korean Society for Applied Biological Chemistry volume 58, pages927-936|[3]Shuhua Tong, et al. Pharmacokinetics and bioavailability of liensinine in mouse blood by UPLC-MS/MS. Acta Chromatographica,Volume 33: Issue 4,14 Oct 2020.
CAS Number
– 2586-96-1
Molecular Weight
– 610.74
Compound Purity
– 99.97
SMILES
– OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC5=C(C=C4OC)CCN(C)[C@@H]5CC6=CC=C(O)C=C6
Clinical Information
– Phase 2
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Mitophagy
Pathway
– Apoptosis;Autophagy
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
