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Lidocaine
$55 – $106
Products Details
Product Description
– Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
Web ID
– HY-B0185
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H22N2O
Citations
– Dig Dis Sci. 2021 Jan 12.|Int Immunopharmacol. 2023 Jan 11;115:109706.|J Neuroinflammation. 2017 Nov 2;14(1):211.|Mol Med Rep. 2022 May;25(5):150.|Nat Methods. 2021 Jul;18(7):788-798.|Neurogastroenterol Motil. 2023 Sep 21;e14677.|PLoS Pathog. 2023 Feb 3;19(2):e1011126.|Stem Cell Res Ther. 2021 Feb 4;12(1):107.|University of Glasgow. School of Cancer Sciences.|Eur Spine J. 2022 Sep 24.|J Phys D Appl Phys. 2019 Aug; 52(46).
References
– [1]Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine’s use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11.|[2]Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19(1):233.|[3]Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113(1):31-6.
CAS Number
– 137-58-6
Molecular Weight
– 234.34
Compound Purity
– 99.96
SMILES
– O=C(NC1=C(C)C=CC=C1C)CN(CC)CC
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : ≥ 5 mg/mL
Target
– Apoptosis;ERK;MEK;NF-κB;Sodium Channel
Isoform
– ERK;MEK;NF-κB
Pathway
– Apoptosis;MAPK/ERK Pathway;Membrane Transporter/Ion Channel;NF-κB;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
