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Product Description
– Licofelone-d6 is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].
Web ID
– HY-B1452S1
Shipping
– Room temperature
Molecular Formula
– C23H16D6ClNO2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.|[3]Alvaro-Gracia JM, et al. Licofelone–clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb43 Suppl 1:i21-5.|[4]Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 1037(12):1894-7.
CAS Number
– 1178549-81-9
Molecular Weight
– 385.92
SMILES
– OC(CC1=C(C2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C4N1CC(C([2H])([2H])[2H])(C4)C([2H])([2H])[2H])=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;COX;Lipoxygenase
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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