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Product Description
– Levobupivacaine ((S)-(-)-Bupivacaine) is a long-acting amide local anaesthetic. Levobupivacaine exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer[1][2][3].
Web ID
– HY-B0653
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H28N2O
References
– [1]Sanford M, et al. Levobupivacaine: a review of its use in regional anaesthesia and pain management. Drugs. 2010 Apr 16;70(6):761-91.|[2]Mao SH, et al. Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer. Front Pharmacol. 2021 Jun 9;12:681338.|[3]Marganella C, et al. Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. Eur J Pharmacol. 2005 Aug 22;518(2-3):111-5.
CAS Number
– 27262-47-1
Molecular Weight
– 288.43
SMILES
– O=C([C@H]1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C
Clinical Information
– Launched
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Ferroptosis;Sodium Channel
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
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