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Levamisole
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Products Details
Product Description
– Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].
Web ID
– HY-A0106
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C11H12N2S
Citations
– Rapid Commun Mass Spectrom. 2022 Nov 16;e9430.|bioRxiv. 2023 Oct 15.|Environ Sci Pollut Res Int. 2022 Sep 16.
References
– [1]Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. |[2]Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158.
CAS Number
– 14769-73-4
Molecular Weight
– 204.29
Compound Purity
– 99.96
SMILES
– C12=N[C@@H](C3=CC=CC=C3)CN1CCS2
Clinical Information
– Launched
Research Area
– Infection; Inflammation/Immunology; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– nAChR;Parasite
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
