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Product Description
– Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
Web ID
– HY-18234
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C20H38N6O4
Citations
– Biochim Biophys Acta Mol Cell Res. 2023 Jan 24;1870(3):119433.|Carbohydr Polym. 2023 Jun 9, 121108.|Emerg Microbes Infect. 2023 Apr 26;2207688.|Int J Biol Macromol. 2023 Jul 3;125670.|Nature. 2023 Jun;618(7966):799-807.|Antiviral Res. 2020 Oct;182:104922.|Autophagy. 2021 Aug;17(8):1873-1888.|Autophagy. 2021 Jul;17(7):1592-1613.|Biochem Pharmacol. 2022: 115339.|bioRxiv. 2020 Jun.|Br J Pharmacol. 2023 Feb 14.|Cancer Lett. 2022 Mar 9;215629.|Cell Death Differ. 2022 Aug 22.|Cell Death Dis. 2022 Oct 12;13(10):865.|Cell Rep. 2021 Nov 2;37(5):109931.|Environ Toxicol. 2023 Nov 23.|Int J Oncol. 2019 Jul;55(1):331-339.|J Biol Chem. 2021, 100616.|J Clin Invest. 2022 Mar 1;132(5):e152170.|Mol Biomed. 2023 Nov 17;4(1):42.|Natl Sci Rev. 2021 Feb 10;8(7):nwab024.|Neuro Oncol. 2022 Jun 21;noac157.|Oncol Rep. 2021 Dec;46(6):253.|Sci Adv. 2021 Jan 1;7(1):eabe1340.|Sci Rep. 2022 Jul 16;12(1):12197.|Toxicol Appl Pharmacol. 2023 May 26;116568.
References
– [1]Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021.|[2]Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42.|[3]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.|[4]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
CAS Number
– 55123-66-5
Molecular Weight
– 426.55
SMILES
– O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin;Ser/Thr Protease;Virus Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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