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Products Details
Product Description
– Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC50s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)[1].
Web ID
– HY-155723
Shipping
– Room temperature
Molecular Formula
– C21H22N4OS
References
– [1]Deau E, et al. Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. J Med Chem. 2023 Aug 10;66(15):10694-10714.
CAS Number
– 2732859-57-1
Molecular Weight
– 378.49
SMILES
– O=C(N1)/C(N=C1NC2(C3)C[C@H]4C[C@@H]3C[C@@H](C2)C4)=C/C5=CC=C(N=CS6)C6=C5
Clinical Information
– No Development Reported
Research Area
– others
Solubility
– 10 mM in DMSO
Target
– CDK;DYRK
Pathway
– Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
