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Products Details
Product Description
– Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent[1].
Web ID
– HY-N10332
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H22O5
References
– [1]Soichiro Nishimura, et al. Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus <i>Remotididymella</i> sp. Bioorg Med Chem Lett. 2022 Ma
CAS Number
– 138039-33-5
Molecular Weight
– 354.40
SMILES
– OC1=C2C(C=C(C(C2=O)=O)OC)=CC3=C1COC(/C(C)=C/C(C)CC)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Proteasome
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
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